Study of variants in the mTOR gene with asthma and therapeutic control in a population of Salvador/BA
Estudo de variantes no gene mTOR com asma e controle terapêutico em uma população de Salvador/BA
Ítalo Santos Uzêda; Raisa Coelho; Ryan Santos Costa; Camila Figueiredo
Abstract
Introduction: Asthma is an inflammatory airway disease that is influenced by several factors. An evolutionarily conserved serine/ threonine kinase named mTOR plays a key role in the integration of environmental signals in the form of growth factors, amino acids, and energy. In the immune system, mTOR is a critical regulator. The mTOR pathway exerts central control over processes in the immune response and in T-cell proliferation, multiplication, and differentiation. Variations in the gene responsible for mTOR complexes have been associated with different critical levels of cytokines, increased likelihood of developing asthma, and increased prevalence of atopy. Objective and method: This study aimed to investigate the association of mTOR gene variants with asthma, asthma severity, and atopy, as well as to perform a cytokine analysis. Result and conclusion: The findings reinforce the importance of mTOR gene variants in the development of asthma.
Keywords
Resumo
Introdução: A asma é uma doença inflamatória das vias aéreas, com diversos fatores influenciando essa condição inflamatória. A mTOR, uma serina/treonina quinase evolutivamente conservada, desempenha um papel central na integração de sinais ambientais na forma de fatores de crescimento, aminoácidos e energia. No sistema imunológico, a mTOR se apresenta como um regulador crítico. A via mTOR se destaca pelo controle central na resposta do sistema imunológico, bem como na proliferação, multiplição e diferenciação das células T. Variações no gene responsável pelos complexos mTOR têm sido associadas a diferentes níveis críticos de citocinas, aumento da probabilidade de desenvolver asma e aumento da prevalência de atopia. Objetivo e método: O objetivo do presente estudo foi investigar a associação entre as variantes do gene mTOR com asma e sua gravidade, atopia, além da análise de citocinas. Resultado e conclusão: Os achados reafirmam a importância das variantes do gene mTOR no desenvolvimento da asma.
Palavras-chave
Referências
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Submetido em:
30/06/2021
Aceito em:
12/10/2021
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