Arquivos de Asma, Alergia e Imunologia
https://aaai-asbai.org.br/article/doi/10.5935/2526-5393.20210053
Arquivos de Asma, Alergia e Imunologia
Special Article

Guia Prático de Atualização no tratamento da exacerbação de asma na criança e no adolescente – Posicionamento conjunto da Associação Brasileira de Alergia e Imunologia e Sociedade Brasileira de Pediatria

Practical Update Guide on the treatment of asthma exacerbation in children and adolescents – Joint position of the Brazilian Association of Allergy and Immunology and the Brazilian Society of Pediatrics

Antonio Carlos Pastorino; Joseane Chiabai; Débora Carla Chong-Silva; Fabio Chigres Kuschnir; Adriana Azoubel-Antunes; Cristine Secco Rosário; Marisa Lages Ribeiro; Carlos Antônio Riedi; Patrícia Gomes de Matos Bezerra; Herberto Jose Chong-Neto; Gustavo Falbo Wandalsen; Maria de Fátima Pombo Sant'Anna; Emanuel Sarinho; Luciana R. Silva; Norma de Paula M. Rubini; Dirceu Solé

Downloads: 0
Views: 90

Resumo

Exacerbação aguda de asma é uma condição frequente na criança e no adolescente e uma das causas mais comuns de procura aos pronto atendimentos e de internações. Pode ocorrer em pacientes que ainda não foram diagnosticados como asmáticos, e mesmo naqueles cujo controle da doença não se encontre adequado. Reconhecer a exacerbação e iniciar seu tratamento desde o domicílio até o adequado manejo inicial em ambiente hospitalar é fundamental para evitar sua evolução para complicações que coloquem o paciente em risco de vida. O tratamento compreende o reconhecimento e tratamento da hipoxemia, da obstrução e do processo inflamatório, além de fornecer orientações na alta hospitalar e encaminhamentos para continuidade do tratamento.

Palavras-chave

Asma aguda, exacerbação da asma, criança, adolescente, tratamento.

Abstract

Acute exacerbation of asthma is a frequent condition in children and adolescents and one of the most common causes of seeking emergency care and hospitalization. It can occur in patients who have not yet been diagnosed with asthma, and even in those whose disease control is not adequate. Recognizing the exacerbation and starting its treatment from home until proper initial management in a hospital environment is essential to avoid its evolution to complications that put the patient at risk of life. Treatment comprises the recognition and treatment of hypoxemia, obstruction, and the inflammatory process, in addition to providing guidance at hospital discharge and referrals for continued treatment.

Keywords

Acute asthma, asthma exacerbation, child, adolescent, treatment.

References

1. Global Initiative for Asthma – GINA - update 2021 [Internet]. Disponível em: www.ginasthma.org. Acessado em: maio/2021.

2. Hasegawa K, Craig SS, Teach SJ, Camargo Jr. CA. Management of asthma exacerbations in the emergency department. J Allergy Clin Immunol Pract. 2021;9(7):2599-610.

3. Tiotiu AI, Novakova P, Nedeva D, Chong-Neto HJ, Novakova S, Steiropoulos P, et al. Impact of air pollution on asthma outcomes. Int J Environ Res Public Health. 2020;17(17):6212.

4. D’Amato G, Chong-Neto HJ, Monge Ortega OP, Vitale C, Ansotegui I, Rosario N, et al. The effects of climate change on respiratoryallergy and asthma induced by pollen and mold allergens. Allergy. 2020;75:2219-28.

5. Stenson E, Tchou M, Wheeler D. Management of acute asthma exacerbations. Curr Opin Pediatr. 2017;29:305-10.

6. Scarfone RJ. Acute asthma exacerbations in children younger than

12 years: Emergency department management. UpToDate 2021. Disponível em: https://www.uptodate.com/contents/acute-asthmaexacerbations-in-children-younger-than-12-years-emergencydepartment-management. Acessado em: 10/06/2021.

7. Gouin S, Robidas I, Gravel J, Guimont C, Chalut D, Amre D. Prospective evaluation of two clinical scores for acute asthma in children 18 months to 7 years of age. Acad Emerg Med. 2010;17(6):598-603.

8. Chalut DS, Ducharme FM, Davis GM. The Preschool Respiratory Assessment Measure (PRAM): a responsive index of acute asthma severity. J Pediatr. 2000;137:762-8.

9. Gorelick MH, Stevens MW, Schultz TR, Scibano PV. Performance ofa novel clinical score, the pediatric Asthma Severity Score (PASS), in the evaluation of acute asthma. Acad Emerg Med. 2004;11:10-8.

10. Kline-Krammes S, Patel NH, Robinson S. Childhood asthma: a guide for pediatric emergency medicine providers. Emerg Med Clin North Am. 2013;31(3):705-32.

11. Castro-Rodríguez JA. Tratamiento de la crisis asmática en pediatría Management of acute asthma exacerbations in pediatrics. An Pediatr (Barc). 2007;67(4):390-400.

12. Tal A, Pasterkamp H, Leahy F. Arterial oxygen desaturation following salbutamol inhalation in acute asthma. Chest. 1984;86(6):868-9.

13. Shein SL, Speicher RH, Filho JO, Gaston B, Rotta AT. Contemporary treatment of children with critical and near-fatal asthma. Rev Bras Ter Intensiva. 2016;28(2):167-78.

14. Le Conte P, Terzi N, Mortamet G, Abroug F, Carteaux G, Charasse C, Chauvin A et al. Management of severe asthma exacerbation: guidelines from the Société Française de Médecine d'Urgence, the Société de Réanimation de Langue Française and the French Group for Pediatric Intensive Care and Emergencies. Ann Intensive Care. 2019;9(1):115.

15. Chao KY, Chien YH, Mu SC. High-flow nasal cannula in children with asthma exacerbation: A review of current evidence. Paediatr Respir Rev. 2021:S1526-0542(21)00003-8.

16. Lee MO, Sivasankar S, Pokrajac N, Smith C, Lumba-Brown A. Emergency department treatment of asthma in children: A review. J Am Coll Emerg Physicians Open. 2020;1(6):1552-61.

17. Fergeson JE, Patel SS, Lockey RF. Acute asthma, prognosis, and treatment. J Allergy Clin Immunol. 2017;139(2):438-47.

18. Miller EK, Avila PC, Khan YW, Word CT, Pelz BJ, Papadopoulos NG, et al. Wheezing exacerbations in early childhood: evaluation, treatment, and recent advances relevant to the genesis of asthma. J Allergy Clin Immunol Pract. 2014;2(5):537-43.

19. Camargo CA, Rachelefsky G, Schatz M. Managing Asthma Exacerbations in the Emergency Department: Summary of the National Asthma Education and Prevention Program Expert Panel Report 3 Guidelines for the Management of Asthma Exacerbations. Proc Am Thorac Soc. 2009;6(4):357-66.

20. Hasegawa K, Sullivan A, Tsugawa Y, Turner, S. Comparison of US emergency department acute asthma care quality: 1997-2001 and 2011-2012. J Allergy Clin Immunol. 2014;135(1):73-80.

21. Waseem M, Leber M, Wasserman E, Sullivan A, Camargo CA, Hasegawa K. Factors associated with concordance with the non-level-A guideline recommendations for emergency department patients with acute asthma. J Allergy Clin Immunol. 2015;3(4):618‑20.

22. Castro-Rodriguez JA, J Rodrigo G, E Rodríguez-Martínez C. Principal findings of systematic reviews of acute asthma treatment in childhood. J Asthma. 2015;52(10):1038-45.

23. Indinnimeo L, Chiappini E, Miraglia Del Giudice M; Italian Panel for the management of acute asthma attack in children Roberto Bernardini. Guideline on management of the acute asthma attack in children by Italian Society of Pediatrics. Ital J Pediatr. 2018;44(1):46.

24. Scarfone RJ, Fuchs SM, Nager AL, Shane SA. Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma. Pediatrics. 1993;92(4):513-8.

25. Cates CJ, Welsh EJ, Rowe BH. Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma. Cochrane database Syst Rev. Cochrane Database Syst Rev. 2013;9:CD000052.

26. Brown JH, Brandl K, Wess J. Agonistas e antagonistas dos receptores muscarínicos. In: Brunton L, Hilal-Dandan R, Knollman B. As bases farmacológicas da terapêutica de Goodman e Gilman. 13ª ed. Porto Alegre: AMG; 2019. p. 181-96.

27. Rodrigo GJ, Castro-Rodriguez JA. Anticholinergics in the treatment of children and adults with acute asthma: a systematic review with meta-analysis. Thorax. 2005;60(9):740-6.

28. Craig SS, Dalziel SR, Powell CV, Graudins A, Babl FE, Lunny C. Interventions for escalation of therapy for acute exacerbations of asthma in children: an overview of Cochrane Reviews. Cochrane Database Syst Rev. 2020 Aug 5;8(8):CD012977.

29. Powell C, Dwan K, Milan SJ, Beasley R, Hughes R, Knopp-Sihota JA, et al. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database Syst Rev. 2012 Dec 12;12:CD003898.

30. Knightly R, Milan SJ, Hughes R, Knopp-Sihota JA, Rowe BH, Normansell R, et al. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database Syst Rev. 2017 Nov 28;11(11):CD003898.

31. Pardue Jones B, Fleming GM, Otillio JK, Asokan I, Arnold DH. Pediatric acute asthma exacerbations: Evaluation and management from emergency department to intensive care unit. J Asthma. 2016;53(6):607-17.

32. Rowe BH, Spooner C, Ducharme FM, Bretzlaff JA, Bota GW. Early ED treatment of acute asthma with systemic corticosteroids. Cochrane Database Syst Rev. 2001;1:Cd002178.

33. Keeney GE, Gray MP, Morrison AK, Levas MN, Kessler EA, Hill GD, et al. Dexamethasone for acute asthma exacerbations in children: a meta-analysis. Pediatrics. 2014;133:493-9.

34. Maselli DJ, Peters JI. Medication Regimens for Managing Acute Asthma. Respir Care. 2018;63(6):783-96.

35. Lahn M, Bijur P, Gallagher EJ. Randomized clinical trial of intramuscular vs oral methylprednisolone in the treatment of asthma exacerbations following discharge from an emergency department. Chest. 2004;126(2):362-8.

36. Rowe BH, Spooner CH, Ducharme FM, Bretzlaff JA, Bota GW. Corticosteroids for preventing relapse following acute exacerbations of asthma. Cochrane Database Syst Rev 2007;(3):CD000195.

37. Ducharme FM, Chabot G, Polychronakos C, Glorieux F, Mazer B. Safety profile of frequent short courses of oral glucocorticoids in acute pediatric asthma: impact on bone metabolism, bone density, and adrenal function. Pediatrics. 2003;111:376-83.

38. Edmonds ML, Milan SJ, Camargo CA Jr, Pollack CV, Rowe BH. Early use of inhaled corticosteroids in the emergency department treatment of acute asthma. Cochrane Database Syst Rev. 2012 Dec 12;12(12):CD002308. 39. Özdemir A, Dogruel D. Efficacy of Magnesium Sulfate Treatment in Children with Acute Asthma. Med Princ Pract. 2020;29:292-8.

40. Irazuzta JE, Chiriboga N. Magnesium sulfate infusion for acute asthma in the emergency department. J Pediatr(Rio J). 2017;93:19‑25.

41. Liu X, Yu T, Rower JE, Campbell SC, Sherwin CM, Johnson MD. Optimizing the use of intravenous magnesium sulfate for acute asthma treatment in children. Pediatr Pulmonol. 2016;51(12):1414‑21.

42. Kenyon CC, Fieldston ES, Luan X, Keren R, Zorc JJ. Safety and effectiveness of continuous aerosolized albuterol in the non- intensive care setting. Pediatrics. 2014;134(4):e976-82.

43. Camargo CA, Spooner C, Rowe BH. Continuous versus intermittent β-agonists for acute asthma. Cochrane Database Syst Rev. 2003;(4):CD001115).

44. Pertzborn MC, Prabhakaran S, Abu-Hasan M, Baker D, Wu S, Wu P, et al. Continuous Albuterol with Benzalkonium in Children Hospitalized With Severe Asthma. Pediatrics. 2020;145(4):e20190107.

45. Travers AH, Milan SJ, Jones AP, Camargo CA Jr., Rowe BH. Addition of intravenous beta(2)-agonists to inhaled beta(2)-agonists for acute asthma. Cochrane Database Syst Rev. 2012;12:CD010179.

46. Bogie AL, Towne D, Luckett PM, Abramo TJ, Wiebe RA. Comparison of intravenous terbutaline versus normal saline in pediatric patients on continuous high-dose nebulized albuterol for status asthmaticus. Pediatr Emerg Care. 2007;23(6):355-61.

47. Rehder KJ. Adjunct Therapies for Refractory Status Asthmaticus in Children. Respir Care. 2017;62(6):849-65.

48. Hon KL, Leung AK. Medications and Recent Patents for status asthmaticus in children. Recent Pat Inflamm Allergy Drug Discov. 2017;11(1):12-21.

49. Mitra A, Bassler D, Goodman K, Lasserson TJ, Ducharme FM. Intravenous aminophylline for acute severe asthma in children over two years receiving inhaled bronchodilators. Cochrane Database Syst Rev. 2005;(2):CD001276.

50. Roberts G, Newsom D, Gomez K, Raffles A, Saglani S, Begent J, et al. Intravenous salbutamol bolus compared with an amino- phylline infusion in children with severe asthma: a randomized controlled trial. Thorax. 2003; 58:306-10.

51. Goyal S, Agrawal A. Ketamine in status asthmaticus: a review. Indian J Crit Care Med. 2013;17(3):154-61.

52. Heshmati F, Zeinali MB, Noroozinia H, Abbacivash R, Mahoori A. Use of ketamine in severe status asthmaticus in intensive care unit. Iran J Allergy Asthma Immunol. 2003;2(4):175-80.

53. Hess DR, Fink JB, Venkataraman ST, Kim IK, Myers TR, Tano BD. The history and physics of heliox. Respir Care. 2006;51(6):608‑12.

54. Rodrigo G, Pollack C, Rodrigo C, Rowe BH. Heliox for nonintubated acute asthma patients. Cochrane Database Syst Rev. 2003;(4):CD002884.

55. Braun Filho LR, Amantéa SL, Becker A, Vitola L, Marta VF, Krumenauer R. Use of helium-oxygen mixture (Heliox) in the treatment of obstructive lower airway disease in a pediatric emergency department. J Pediatr(Rio J). 2010;86(5):424-8.

56. Rodrigo GJ, Castro-Rodriguez JA. Heliox-driven beta2-agonists nebulization for children and adults with acute asthma: a systematic review with meta-analysis. Ann Allergy Asthma Immunol. 2014;112(1):29-34.

57. Mayordomo-Colunga J, Medina A, Rey C, Concha A, Menendez S, Arcos ML, et al. Non-invasive ventilation in pediatric status asthmaticus: a prospective observational study. Pediatr Pulmonol. 2011;46(10):949-55.

58. Carroll CL, Schramm CM. Noninvasive positive pressure ventilation for the treatment of status asthmaticus in children. Ann Allergy Asthma Immunol. 2006;96(3):454-9.

59. Kelly GS, Simon HK, Sturm JJ. High-flow nasal cannula use in children with respiratory distress in the emergency department: predicting the need for subsequent intubation. Pediatr Emerg Care. 2013;29(8):888-92.

60. Benítez RG, Sanabria LPM, Pavlicich V, Mesquita M. High flow nasal cannula oxygen therapy in patients with asthmatic crisis in the pediatric emergency department. Rev Chil Pediatr. 2019;90(6):642-8.

61. Graham V, Lasserson T, Rowe BH. Antibiotics for acute asthma. Cochrane Database Syst Rev. 2001;(3):CD002741.

62. Kew KM, Undela K, Kotortsi I, Ferrara G. Macrolides for chronic asthma. Cochrane Database Syst Rev. 2015;(9):CD002997.

63. Char DS, Ibsen LM, Ramamoorthy C, Bratton SL. Volatile anesthetic rescue therapy in children with acute asthma: innovative but costly or just costly? Pediatr Crit Care Med. 2013;14(4):343-50.

64. Masuda Y, Tatsumi H, Goto K, Imaizumi H, Yoshida S, Kimijima T, et al. Treatment of life-threatening hypercapnia with isoflurane in an infant with status asthmaticus. J Anesth. 2014;28(4):610-2.

65. British Thoracic Society, Scottish Intercollegiate Guidelines Network. British guideline on the Management of Asthma: A national clinical guideline. Revised 2016. London: British Thoracic Society, Scottish Intercollegiate Guidelines Network; 2016. 214p.

66. Keahey L, Bulloch B, Becker AB, Pollack CV Jr, Clark S, Camargo CA Jr; Multicenter Asthma Research Collaboration (MARC) Investigators. Initial oxygen saturation as a predictor of admission in children presenting to the emergency department with acute asthma. Ann Emerg Med. 2002;40(3):300-7.

67. Carroll CL, Sala KA. Pediatric status asthmaticus. Crit Care Clin. 2013;29(2):153-66.

68. Powell, Colin VE. Acute severe asthma. J Paediatr Child Health. 2016;52(2):187-91.

69. 2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. (NIH publication no. 20-HL-8140). Bethesda, MD: National Heart, Lung, and Blood Institute, 2020. Available from: http//www.nhlbi.nih.gov/health-topics/asthma-management-guidelines-2020-updates.

70. Proença Filho JO, Freddi NA. Estado de mal asmático. In: Hirschheimer MR, Carvalho WB, Matsumoto T, editors. Terapia intensiva pediátrica e neonatal. 4ª ed. Rio de Janeiro: Atheneu; 2018. p. 549-86.

71. Koninckx M, Buysse C, de Hoog M. Management of status asthmaticus in children. Paediatr Respir Rev. 2013;14:78.

72. Leatherman, J. Mechanical Ventilation for Severe Asthma. Chest. 2015;147(6):1671-80.

73. Swern AS, Tozzi CA, Knorr B, Bisgaard H. Predicting an asthma exacerbation in children 2 to 5 years of age. Ann Allergy Asthma Immunol. 2008;101:626-30.

74. Grant CC, Duggan AK, DeAngelis C. Independent parental administration of prednisone in acute asthma: a double-blind, placebo-controlled, crossover study. Pediatrics. 1995;96:224-9.

75. Vuillermin P, South M, Robertson C. Parent-initiated oral corticosteroid therapy for intermittent illnesses in children. Cochrane Database Syst Rev. 2006:D005311.

76. Kaiser SV, Huynh T, Bacharier LB, Rosenthal JL, Bakel LA, Parkin PC, et al. Preventing exacerbations in preschoolers with recurrent wheeze: a meta-analysis. Pediatrics. 2016;137(6):e20154496.

77. Robertson CF, Price D, Henry R, Mellis C, Glasgow N, Fitzgerald D, et al. Short-course montelukast for intermittent asthma in children: a randomized controlled trial. Am J Respir Crit Care Med. 2007;175:323-9.

78. FDA requires Boxed Warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis. FDA, 2020. Disponível em: http://www.fda.gov/drugs/drug-safety-and-availability/fda-requires-boxedwarning-about-serious-mental-health-side-effects-asthma-andallergy-drug. Acessado em: 21/06/2021.

79. Chan M, Gray M, Burns C, Owens L, Woolfenden S, Lingam R, et al. Community-based interventions for childhood asthma using comprehensive approaches: a systematic review and meta-analysis. Allergy Asthma Clin Immunol. 2021;17(1):19.

80. Song W-J, Won H-K, Lee SY, Park H-K, Cho YS, Chung KF, et al. Patients’ experiences of asthma exacerbation and management: a qualitative study of severe asthma. ERJ Open Res. 2021;7(2):00528‑2020.

81. Glick AF, Farkas JS, Nicholson J, Dreyer BP, Fears M, Bandera C, et al. Parental Management of Discharge Instructions: A Systematic Review. Pediatrics. 2017;140(2):e20164165.

82. Krupp NL, Fiscus C, Webb R, Webber EC, Stanley T, Pettit R, et al. Multifaceted quality improvement initiative to decrease pediatric asthma readmissions. J Asthma. 2017;54(9):911-8.

83. Parikh K, Hall M, Kenyon CC, Teufel RJ 2nd, Mussman GM, Montalbano A, et al. Impact of Discharge Components on Readmission Rates for Children Hospitalized with Asthma. J Pediatr. 2018;195:175-81.


Submitted date:
08/28/2021

Accepted date:
09/06/2021

6a146b4aa953952abf1748a7 aaai Articles
Links & Downloads

Arq Asma Alerg Imunol

Share this page
Page Sections