Arquivos de Asma, Alergia e Imunologia
https://aaai-asbai.org.br/article/doi/10.5935/2526-5393.20190050
Arquivos de Asma, Alergia e Imunologia
Special Article

Guia para o manejo da asma grave 2019 – Associação Brasileira de Alergia e Imunologia

Guide to the management of severe asthma 2019 – Brazilian Association of Allergy and Immunology

Gustavo F. Wandalsen; Flávio Sano; Ana Carla A. M. Falcão; Adelmir S. Machado; Faradiba S. Serpa; José Ângelo Rizzo; José Elabras Filho; Pedro Giavina-Bianchi; Tessa R. T. Gonçalves; Dirceu Solé

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Resumo

Antes de rotular um paciente como tendo asma grave, é crucial confirmar o diagnóstico da doença e de sua gravidade, além de excluir diagnósticos diferenciais de condições que podem se assemelhar ou se confundir com a asma, tais como: tuberculose, doença pulmonar obstrutiva crônica, disfunção de corda vocal, apneia do sono, bronquiectasia, entre outras. Neste guia são abordados, além dos diagnósticos diferenciais, dados de história clínica e exames laboratoriais que permitem classificar o paciente com relação à evolução da doença (controlado ou não controlado) e, assim, possibilitar a instituição do esquema terapêutico mais apropriado. São apresentadas alternativas terapêuticas disponíveis para a abordagem clínica desses pacientes, incluindo os imunobiológicos.

Palavras-chave

Asma grave, controle da asma, corticosteroide inalado, imunobiológicos, qualidade de vida, anticorpos monoclonais.

Abstract

Prior to labeling a patient as having severe asthma, a crucial step is to confirm the diagnosis and severity as well as to exclude conditions that may resemble or be mistaken for asthma such as tuberculosis, chronic obstructive pulmonary disease, vocal cord dysfunction, sleep apnea, bronchiectasis, among others. In addition to differential diagnoses, this guide addresses clinical history data and laboratory tests that classify the patient regarding disease progression (controlled or uncontrolled asthma), allowing the establishment of an adequate therapeutic plan. Therapeutic options available for the treatment of these patients are detailed, including biologics.

Keywords

Severe asthma, asthma control, inhaled corticosteroid, biologics, quality of life, monoclonal antibodies.

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Submitted date:
11/10/2019

Accepted date:
12/10/2019

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