Receptor MrgprX2 nas anafilaxias não alérgicas
MRGPRX2 receptor in non-allergic anaphylaxis
Danilo Gois Gonçalves; Pedro Giavina-Bianchi
Resumo
A identificação e descrição das propriedades do receptor MrgprX2 possibilitou maior compreensão das funções dos mastócitos nas reações de hipersensibilidade não alérgicas, assim como em processos inflamatórios e infecciosos. Neste artigo revisamos brevemente as principais funções deste receptor, enfatizando seu papel nas reações de hipersensibilidade a medicamentos, promovendo a desgranulação direta de mastócitos.
Palavras-chave
Abstract
The Identification identification of the receptor MRGPRX2 receptor and the description of its properties has improved the knowledge about mast cell actions in non-allergic hypersensitivity reactions, as well as in inflammatory and infectious processes. In this paper we briefly review the main functions of this receptor, highlighting its role in the drug-induced hypersensitivity reactions, with direct degranulation of mast cells.
Keywords
Referências
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Submetido em:
09/03/2018
Aceito em:
09/07/2018
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