Arquivos de Asma, Alergia e Imunologia
https://aaai-asbai.org.br/article/doi/10.5935/2526-5393.20180031
Arquivos de Asma, Alergia e Imunologia
Comunicação Clínica e Experimental

Uso de leite processado em altas temperaturas por paciente com alergia ao leite de vaca - relato de caso

Use of milk processed at high temperatures by a patient with cow’s milk allergy: case report

Renata Magalhães Boaventura; Raquel Bicudo Mendonça; Roseani da Silva Andrade; Elaine Cristina de Almeida Kotchetkoff; Roseli Oselka Saccardo Sarni

Downloads: 0
Views: 39

Resumo

Objetivo: Relatar a evolução clínica de um escolar com alergia ao leite de vaca (ALV) que fez uso de leite de vaca processado em altas temperaturas (LVPAT). Descrição: H.B.M., sexo masculino, 7 anos, com ALV IgE mediada diagnosticada com 1 ano e 3 meses. Aos 2 anos foi submetido a teste de provocação oral (TPO) aberto para leite de vaca (LV) in natura, evoluindo com urticária, congestão nasal e vômito após a primeira dose (1 mL). Mãe relatou alguns episódios de exposição acidental ao LV acompanhados de sintomas. As Imunoglobulinas E para LV e frações mantiveram-se elevadas (IgE leite total: 4,69 KU/L) até os 6 anos, quando a criança realizou TPO com LVPAT, sob a forma de bolo, evoluindo sem intercorrências. Passou a consumir diariamente uma porção do bolo contendo leite processado durante 6 meses. Aos 7 anos e com IgEs específicas mais baixas (IgE específica leite total: 2,2 KU/L), realizou TPO com LV in natura sem sintomas, sendo liberado na dieta. Comentários: O uso do leite de vaca processado em altas temperaturas em pacientes com ALV IgE mediada é uma estratégia promissora com impacto na tolerância futura ao alimento, tendo resultados favoráveis com ênfase na qualidade de vida e inclusão social. No entanto, vale ressaltar a importância da avaliação individualizada dos pacientes e a segurança da equipe na aplicação desses protocolos, além de levar em consideração que a alergia pode ser transitória, mesmo sem o uso do leite processado.

Palavras-chave

Hipersensibilidade a leite, hipersensibilidade alimentar, diagnóstico.

Abstract

Objective: To report the clinical evolution of a school-age boy with cow’s milk allergy CMA) who made use of cow’s milk processed at high temperatures (CMPHT). Description: H.B.M., male, 7 years old, was diagnosed with IgE-mediated CMA at 1 year and 3 months of age. At 2 years of age, the patient underwent an open oral food challenge for raw cow’s milk (CM) and developed urticaria, nasal congestion and vomiting after the first dose (1 mL). The mother reported some episodes of accidental exposure to CM, accompanied by symptoms. Specific IgEs against CM and its fractions remained elevated (total cow’s milk: 4.69 KU/L) until 6 years of age, when the patient underwent a new oral food challenge for CMPHT, in the form of a cake, without symptoms. He then began to consume a portion of cake containing baked milk daily, for 6 months. At the age of 7 and with lower levels of specific IgEs (total cow’s milk: 2.2 KU/L), he underwent another oral food challenge for raw CM, without symptoms. An unrestricted diet was then authorized. Comments: The use of cow’s milk processed at high temperatures in patients with IgE-mediated cow’s milk allergy is a promising strategy, with impact on future food tolerance, favorable results, with emphasis on quality of life and social inclusion. However, an individualized assessment of each patient is extremely important, as is the confidence of the team while applying these protocols. It should be taken into consideration that the allergy may be transient even without the use of processed milk.

Keywords

Cow’s milk allergy, food allergy, diagnosis.

Referências

1. Robison RG. Food allergy: Diagnosis, management & emerging therapies. 2014;139(6):805-13.

2. Radlovic N, Lekovic Z, Radlovic V, Simic D, Ristic D, Vuletic B. Food allergy in children. Srp Arh Celok Lek. 2016;144(1-2):99-103.

3. Boyce JA, Jones SM, Rock L, Sampson HA, Cooper SF, Boyce S, et al. Guidelines for the diagnosis and management of food allergy in the United States: Report of the NIAID-sponsored expert panel. Journal of Allergy and Clinical Immunology. 2010;26:1-58.

4. Koletzko S, Niggemann B, Arato A, Dias JA, Heuschkel R, Husby S, et al. Diagnostic approach and management of cows-milk protein allergy in infants and children. J Pediatr Gastroenterol Nutr. 2012;55(2):221-9.

5. Ebisawa M, Ito K, Fujisawa T. Japanese guidelines for food allergy 2017. Allergol Int. 2017;66(2):248-64.

6. Barbosa CPG, Castro APM, Yonamine GH, Gushken AKF, Beck CML, Macedo PRC, et al. Baked milk tolerant patient: Is there any special feature? Allergol Immunopathol (Madr). 2017;45(3):283-9.

7. Nowak-Wegrzyn A, Fiocchi A. Rare, medium, or well done? The effect of heating and food matrix on food protein allergenicity. Curr Opin Allergy Clin Immunol. 2009;9(3):234-7.

8. Bloom KA, Huang FR, Bencharitiwong R, Bardina L, Ross A, Sampson HA, et al. Effect of heat treatment on milk and egg proteins allergenicity. Pediatr Allergy Immunol. 2014;25(8):740-6.

9. Gupta M, Cox A, Nowak-Wgrzyn A, Wang J. Diagnosis of food allergy. Immunol Allergy Clin North Am. 2018;38(1):39-52.

10. Leonard SA, Caubet JC, Kim JS, Groetch M, Nowak-Wegrzyn A. Baked milk- and egg-containing diet in the management of milk and egg allergy. J Allergy Clin Immunol Pract. 2015;3(1):13-23.

11. Nowak-Wegrzyn A, Bloom KA, Sicherer SH, Shreffler WG, Noone S, Wanich N, et al. Tolerance to extensively heated milk in children with cow’s milk allergy. J Allergy Clin Immunol. 2008;122(2).

12. Kim JS, Nowak-Wgrzyn A, Sicherer SH, Noone S, Moshier EL, Sampson HA. Dietary baked milk accelerates the resolution of cow’s milk allergy in children. J Allergy Clin Immunol. 2011;128(1):125‑31.

13. Bartnikas LM, Sheehan WJ, Hoffman EB, Permaul P, Dioun AF, Friedlander J, et al. Predicting food challenge outcomes for baked milk: Role of specific IgE and skin prick testing. Ann Allergy, Asthma Immunol. 2012;109(5):309-313.e1.

14. Lambert R, Grimshaw KEC, Ellis B, Jaitly J, Roberts G. Evidence that eating baked egg or milk influences egg or milk allergy resolution: a systematic review. Clin Exp Allergy. 2017;47(6):829-37.

15. Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, et al. The natural history of milk allergy in an observational cohort. J Allergy Clin Immunol. 2013;(3):805-12.

16. Goldberg MR, Nachshon L, Appel MY, Elizur A, Levy MB, Eisenberg E, et al. Efficacy of baked milk oral immunotherapy in baked milk-reactive allergic patients. J Allergy Clin Immunol. 2015;136(6):1601-6.


Submetido em:
19/03/2018

Aceito em:
23/03/2018

6a4be155a953955379623473 aaai Articles
Links & Downloads

Arq Asma Alerg Imunol

Share this page
Page Sections