Arquivos de Asma, Alergia e Imunologia
https://aaai-asbai.org.br/article/doi/10.5935/2318-5015.20150030
Arquivos de Asma, Alergia e Imunologia
Relato de Caso

Deficiência seletiva de IgM: relato de caso

Selective IgM deficiency: case report

Juliano José Jorge

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Resumo

Deficiência seletiva de IgM é um defeito imunológico mais comum do que se pensava. Está associada a infecções de repetição, manifestações atópicas, doenças autoimunes e malignidades. Reposição de imunoglobulina é o tratamento de escolha nos pacientes com infecções recorrentes e presença associada de deficiência seletiva de anticorpos.

Palavras-chave

Deficiência IgM, imunodeficiência.

Abstract

Selective IgM deficiency an immunological defect that has been found to be more common than originally thought. It is associated with recurrent infections, atopic manifestations, autoimmune diseases, and malignancies. Immunoglobulin replacement therapy is the treatment of choice for patients with recurrent infections and associated presence of specific antibody deficiencies.

Keywords

IgM deficiency, immunodeficiency.

Referências

1. Louis AG, Gupta S. Primary selective IgM deficiency: an ignored immunodeficiency. Clin Rev Allergy Immunol. 2014;46:104-11.

2. Goldstein MF, Goldstein AL, Dunsky EH, Dvorin DJ, Belecanech GA, Shamir K. Pediatric selective IgM deficiency. Clin Develop Immunol.2008;2008:624850. doi: 10.1155/2008/624850.

3. Yel L, Ramanuja S, Gupta S. Clinical and immunological features in IgM deficiency. Int Arch Allergy Immunol. 2009;150:291-8.

4. Goldstein MF, Goldstein AL, Dunsky EH, Dvorin DJ, Belecanech GA, Shamir K. Selective IgM immunodeficiency: retrospective analysis of 36 adult patients with review of literature. Ann Allergy Asthma Immunol. 2006;97:717-30.

5. Saini S, Dettore AJ, Bhambhani KJ, Buck S, Poulik J, Savaşan S. Selective IgM deficiency in CD30+ cutaneous lymphoproliferative disorder. J Pediatr Hematol Oncol. 2011;33:e156–e159.

6. Kutukculer N, Gulez N. Outcome of patients with unclassified hypogammaglobulinemia in early childhood. Paediatr Allergy Immunol. 2009;20:693-9.

7. Karsh J, Watts CG, Osterland CK. Selective immunoglobulinM deficiency in an adult: Assessment of immunoglobulin production by peripheral blood lymphocytes in vitro. Clin Immunol Immunopathol. 1982;25:386-94.

8. Fallon KE. Inability to train, recurrent infection, and selective IgM deficiency. Clin J Sport Med. 2004;14:357-9.


Submetido em:
29/12/2015

Aceito em:
03/11/2016

6a6a560ca953952ac82028e5 1776695468 Articles
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