Aspectos práticos do teste de provocação nasal específico no Brasil
Practical aspects of the nasal allergen challenge in Brazil
Fausto Yoshio Matsumoto, Danilo Gois Gonçalves, Giovanni Di Gesu, Isabella Diniz Braga Pimentel, João Ferreira Mello Júnior, João Vianney Brito de Oliveira, Maria Cândida Faria Varanda Rizzo, Maria Leticia Freitas Silva Chavarria, Simone Valladão Curi, Maria Elisa Bertocco Andrade, Gustavo Falbo Wandalsen, Fátima Rodrigues Fernandes
Resumo
Os testes de provocação nasal são considerados procedimentos simples e seguros, capazes de avaliar, de forma objetiva e em ambiente seguro e controlado, as respostas da mucosa nasal após o contato com substâncias e/ou estímulos externos aplicados localmente. Sua utilização tem se tornado cada vez mais relevante na prática clínica e representa um ponto de partida essencial para o diagnóstico correto dos diferentes fenótipos de rinite. O objetivo deste estudo é promover a realização do teste de provocação nasal de forma segura e padronizada, conforme as características nacionais. Foi realizada revisão da literatura existente, bem como a descrição das características dos extratos e dos equipamentos disponíveis no Brasil. Apesar de simples, o teste de provocação nasal deve ser realizado em ambiente preparado, com uma equipe técnica bem treinada e utilizando protocolos de aplicação de alérgenos e de monitoramento bem estabelecidos. A padronização dos diferentes alérgenos disponíveis no país é essencial para que os testes sejam mais amplamente utilizados na prática clínica.
Palavras-chave
Abstract
The nasal allergen challenge is a straightforward and safe method that objectively evaluates the nasal mucosa’s response to locally applied substances and/or external stimuli in a controlled environment. These tools have increased markedly in clinical practice, making them a fundamental starting point for accurately diagnosing various rhinitis phenotypes. The objective of this study is to promote the safe and standardized performance of nasal allergen challenge in accordance with national characteristics. A comprehensive review of the extant literature was conducted, encompassing a detailed description of the characteristics of the extracts and equipment available in Brazil. Notwithstanding its simplicity, the nasal allergen challenge must be conducted in a prepared setting, with a welltrained technical team and using well-established protocols for allergen administration and monitoring. Standardizing the allergens available in the country is imperative for wider use of these tests in clinical practice.
Keywords
References
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Submitted date:
07/17/2026
Accepted date:
08/31/2026
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