Arquivos de Asma, Alergia e Imunologia
https://aaai-asbai.org.br/article/doi/10.4322/2526-5393.20250043
Arquivos de Asma, Alergia e Imunologia
Artigo de Revisão

Broncoconstrição induzida pelo exercício

Exercise-induced bronchoconstriction

João Cardoso Lopes, Álvaro Nogueira, Helena Pereira, Pedro Botelho Alves

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Resumo

A broncoconstrição induzida pelo exercício (BIE) é caracterizada pelo estreitamento transitório e reversível das vias aéreas du‑ rante ou após o exercício físico, sendo uma condição frequente em crianças, adultos e, em particular, em atletas. Resulta so‑ bretudo da inflamação das vias aéreas, do arrefecimento do ar inalado e/ou da desidratação da mucosa respiratória induzida pela hiperventilação. Os sintomas mais comuns incluem tosse, sibilância, dispneia e opressão torácica, podendo traduzir-se em fadiga precoce e limitação do desempenho físico. O diagnóstico baseia-se na história clínica, exame objetivo e provas de função respiratória, recorrendo a testes de broncoprovocação específicos para documentar uma diminuição do FEV1 (volume expiratório for‑ çado no 1° segundo) após o esforço ou após estímulos indiretos. A abordagem terapêutica combina medidas não farmacológicas – como otimização do aquecimento pré-exercício e modificação de fatores ambientais – com medidas farmacológicas, incluindo agonistas beta-2 de curta duração, corticosteroides inalados e antagonistas dos receptores dos leucotrienos, selecionados e ajustados de acordo com o contexto clínico e a presença de asma subjacente. Um seguimento estruturado, idealmente em articula‑ ção com equipes de Medicina Desportiva e Imunoalergologia, é fundamental para garantir o controlo dos sintomas, a segurança e a manutenção da prática de atividade física.

Palavras-chave

Broncoconstrição induzida pelo exercício, asma, atletas, provas de função respiratória, beta-agonistas, corticosteroides.

Abstract

Exercise-induced bronchoconstriction (EIB) is defined as a transient, reversible narrowing of the airways that occurs during or after physical exercise and is frequent in children, adults, and athletes. It results primarily from airway inflammation, cooling of inhaled air, and/or dehydration of the respiratory mucosa caused by hyperventilation. Typical symptoms include coughing, wheezing, dyspnea, and chest tightness, which may also manifest as early fatigue and reduced exercise performance. Diagnosis relies on a detailed clinical history, physical examination, and pulmonary function tests, using specific bronchoprovocation protocols to document a reduction in post-exercise forced expiratory volume in one second (FEV1) or after indirect stimuli. Management combines non-pharmacological strategies – including optimization of pre-exercise warm-up routines and reduction of environmental triggers – with pharmacological measures such as short-acting β2-agonists, inhaled corticosteroids, and leukotriene receptor antagonists, tailored to the clinical context and the presence of underlying asthma. Structured follow-up, ideally involving specialists in sports medicine and allergy, is essential to ensure adequate symptom control, patient safety, and maintenance of regular physical activity

Keywords

Exercise-induced bronchoconstriction, asthma, athletes, pulmonary function tests, beta-agonists, corticosteroids.

Referências

1. Riya FNU, Vaqar S. National Guidelines for Physical Activity. [Updated 2023 Aug 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK585062/ .

2. Parsons JP. Exercise-induced bronchoconstriction. Otolaryngol Clin North Am. 2014;47(1):119-26.

3. Weiler JM, Brannan JD, Randolph CC, Hallstrand TS, Parsons J, Silvers W, et al. Exercise-induced bronchoconstriction update-2016. J Allergy Clin Immunol. 2016 Nov;138(5):1292-5.e36. doi: 10.1016/j.jaci.2016.05.029.

4. Mountjoy M, Fitch K, Boulet LP, Bougault V, van Mechelen W, et al. Asthma in Olympic athletes: prevalence and characteristics. J Allergy Clin Immunol. 2015;136(3):588-94.

5. Weiler JM, Bonini S, Coifman R, Craig T, Delgado L, Capão-Filipe M, et al.; Ad Hoc Committee of Sports Medicine Committee of American Academy of Allergy, Asthma & Immunology. American Academy of Allergy, Asthma & Immunology Work Group report: exercise-induced asthma. J Allergy Clin Immunol. 2007 Jun;119(6):1349-58. doi:10.1016/j.jaci.2007.02.041.

6. Carlsen KH, Anderson SD, Bjermer L, Bonini S, Brusasco V, Canonica W, et al.; European Respiratory Society; European Academy of Allergy and Clinical Immunology. Exercise-induced asthma, respiratory and allergic disorders in elite athletes: epidemiology, mechanisms and diagnosis: part I of the report from the Joint Task Force of the European Respiratory Society (ERS) and the European Academy of Allergy and Clinical Immunology (EAACI) in cooperation with GA2LEN. Allergy. 2008 Apr;63(4):387-403. doi:10.1111/j.1398-9995.2008.01662.x.

7. Anderson SD, Daviskas E. The mechanism of exercise-induced asthma is.. J Allergy Clin Immunol. 2000;106(3):453-9. doi: 10.1067/mai.2000.109822.

8. Couto M, Kurowski M, Moreira A, Bullens DMA, Carlsen KH, Delgado L, et al. Mechanisms of exercise-induced bronchoconstriction in athletes: Current perspectives and future challenges. Allergy. 2018 Jan;73(1):8-16. doi: 10.1111/all.13224.

9. Couto M, Jacinto T. Avaliação objetiva no diagnóstico de broncoconstrição induzida pelo exercício. Rev Port Imunoalergologia. 2019;27(4):309-25.

10. Van Schoor J, Joos GF, Pauwels RA. Indirect bronchial hyperresponsiveness in asthma: mechanisms and clinical implications. Eur Respir J. 2000;16:514-33.

11. Price OJ, Walsted ES, Bonini M, Brannan JD, Bougault V, Carlsen KH, et al. Diagnosis and management of allergy and respiratory disorders in sport: An EAACI task force position paper. Allergy. 2022 Oct;77(10):2909-23. doi: 10.1111/all.15431.

12. Boulet LP, O'Byrne PM. Asthma and exercise-induced bronchoconstriction in athletes. N Engl J Med. 2015 Feb 12;372(7):641-8. doi: 10.1056/NEJMra1407552.

13. Rundell KW, Smoliga JM, Bougault V. Exercise-induced bronchoconstriction and the athlete. Immunol Allergy Clin North Am. 2018;38(2):183-204.

14. Klain A, Giovannini M, Pecoraro L, Barni S, Mori F, Liotti L, et al. Exercise-induced bronchoconstriction, allergy and sports in children. Ital J Pediatr. 2024 Mar 13;50(1):47. doi: 10.1186/s13052-02401594-0.

15. Albuquerque Rodrigues Filho E, Rizzo JÂ, Gonçalves AV, Correia Junior MAV, Sarinho ESC, Medeiros D. Exercise-induced bronchospasm in children and adolescents with allergic rhinitis by treadmill and hyperventilation challenges. Respir Med. 2018 May;138:102-6. doi: 10.1016/j.rmed.2018.04.001.

16. Malewska-Kaczmarek K, Podlecka D, Mankowski T, Jerzynska J, Stelmach I. Exercise-Induced Bronchoconstriction in Children: A Comparison between Athletes and Non-Athletes. Healthcare. 2023; 11(9):1349. doi: 10.3390/healthcare11091349.

17. Bougault V, Turmel J, Boulet LP. Bronchial challenges and respiratory symptoms in elite swimmers and winter sport athletes: Airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest. 2010 Aug;138(2 Suppl):31S-37S. doi: 10.1378/ chest.09-1689.

18. World Anti-Doping Agency (WADA). World Anti-Doping Code and Prohibited List (Internet). Disponível em: https://www.wada-ama.org/en/resources/world-anti-doping-code-and-international-standards/ prohibited-list.

19. Freed AN, Davis MS. Hyperventilation with dry air increases airway surface fluid osmolality in canine peripheral airways. Am J Respir Crit Care Med. 1999;159(4 Pt 1):1101-7.

20. Hox V, Vanoirbeek JA, Alpizar YA, Voedisch S, Callebaut I, Bobic S, et al. Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in mice. Am J Respir Crit Care Med. 2013;187(5):486-93.

21. Anderson SD, Kippelen P. Airway injury as a mechanism for exerciseinduced bronchoconstriction in elite athletes. J Allergy Clin Immunol. 2008;122(2):225-35. doi: 10.1016/j.jaci.2008.05.001.

22. Hostrup M, Hansen ESH, Rasmussen SM, Jessen S, Backer V. Asthma and exercise-induced bronchoconstriction in athletes: Diagnosis, treatment, and anti-doping challenges. Scand J Med Sci Sports. 2024 Jan;34(1):e14358. doi: 10.1111/sms.14358.

23. Tufvesson E, Svensson H, Ankerst J, Bjermer L. Increase of club cell (Clara) protein (CC16) in plasma and urine after exercise challenge in asthmatics and healthy controls, and correlations to exhaled breath temperature and exhaled nitric oxide. Respir Med. 2013 Nov;107(11):1675-81. doi: 10.1016/j.rmed.2013.08.004.

24. Parsons JP, Mastronarde JG. Exercise-induced bronchoconstriction: practical aspects of diagnosis and management. Chest. 2005;128(6):3966-74.

25. Boulding R, Stacey R, Niven R, Fowler SJ. Dysfunctional breathing: a review of the literature and proposal for classification. Eur Respir Rev. 2016 Sep;25(141):287-94. doi: 10.1183/16000617.0088-2015.

26. Alving K. FeNO and the Prediction of Exercise-Induced Bronchoconstriction. J Allergy Clin Immunol Pract. 2018 MayJun;6(3):863-4. doi: 10.1016/j.jaip.2017.12.038.

27. Stanojevic S, Kaminsky DA, Miller MR, Thompson B, Aliverti A, Barjaktarevic I, et al. ERS/ATS technical standard on interpretive strategies for routine lung function tests. Eur Respir J. 2022 Jul 13;60(1):2101499. doi: 10.1183/13993003.01499-2021.

28. Venkatesan P. 2023 GINA report for asthma. Lancet Respir Med. 2023 Jul;11(7):589. doi: 10.1016/S2213-2600(23)00230-8.

29. Brannan JD, Porsbjerg C. Testing for Exercise-Induced Bronchoconstriction. Immunol Allergy Clin North Am. 2018 May;38(2):215-229. doi: 10.1016/j.iac.2018.01.010.

30. Christensen PM, Heimdal JH, Christopher KL, Bucca C, Cantarella G, Friedrich G, et al. ERS/ELS/ACCP 2013 international consensus conference nomenclature on inducible laryngeal obstructions. Eur Respir Rev. 2015;24(137):445-50.

31. Weinberger M, Abu-Hasan M. Perceptions and pathophysiology of dyspnea and exercise intolerance. Pediatr Clin North Am. 2009 Feb;56(1):33-48, ix. doi: 10.1016/j.pcl.2008.10.015.

32. Stickland MK, Rowe BH, Spooner CH, Vandermeer B, Dryden DM. Effect of warm-up exercise on exercise-induced bronchoconstriction. Med Sci Sports Exerc. 2012 Mar;44(3):383-91. doi: 10.1249/MSS.0b013e31822fb73a.

33. He T, Song T. Exercise-induced bronchoconstriction in elite athletes: a narrative review. Phys Sportsmed. 2023 Dec;51(6):549-57. doi:10.1080/00913847.2022.2148137.

34. Kansra S, Mazzei A, Bhatt J. Safety, efficacy, and patient acceptability of montelukast in exercise-induced asthma. Clin Med Insights Ther. 2012;4:231-9. doi: 10.4137/CMT.S7389.

35. Boaventura LC, Araujo AC, Martinez JB, Vianna EO. Effects of ipratropium on exercise-induced bronchospasm. Int J Sports Med. 2010 Jul;31(7):516-20. doi: 10.1055/s-0030-1249624.


Submetido em:
16/11/2024

Aceito em:
21/11/2025

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